Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis

BMC Pregnancy and Childbirth

Payam Amini¹  Ahad Alizadeh²  Maryam Mohammadi²  Behnaz Navid²  Reza Omani-Samani²  Amir Almasi-Hashiani³  Esmaeil Khedmati Morasae⁴  Saman Maroufizadeh⁵ 

[1] Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences;Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR;Department of Epidemiology, School of Health, Arak University of Medical Sciences;Institute of Psychology, Health, and Society, Department of Health Services Research, University of Liverpool;School of Nursing and Midwifery, Guilan University of Medical Sciences;

关键词: Assisted reproductive technology;    Preeclampsia;    Infertility;    Meta-analysis;    Systematic review;   

DOI  :  10.1186/s12884-019-2291-x

来源: DOAJ

【 摘 要 】

Abstract Background The objective of this systematic review and meta-analyses was to assess the risk of preeclampsia among women who conceived with assisted reproductive technology (ART). Methods We searched the ISI Web of Knowledge, Medline/PubMed, Scopus, and Embase (from inception to May 2017) for English language articles using a list of key words. In addition, reference lists from identified studies and relevant review articles were also searched. Data extraction was performed by two authors, and the study quality was assessed using the Newcastle–Ottawa Scale. Random-effects model meta-analysis was applied to pool the relative risks (RR) across studies. Results A total of 48 studies (5 case-control studies and 43 cohort studies) were included in this meta-analysis. The Cochran Q test and I2 statistics revealed substantial heterogeneity (Q = 26,313.92, d.f. = 47, p < 0.001 and I2 = 99.8%). Meta-analysis showed a significant increase in preeclampsia in women who conceived by ART compared with those who conceived spontaneously (RR = 1.71, 95% CI = 1.11–2.62, p = 0.015). Conclusions The findings of this systematic review indicate that the use of ART treatment is associated with a 1.71-fold increase in preeclampsia.

【 授权许可】

Unknown