Polymeric coating lubricates nanocontainers to escape macrophage uptake for bioreceptor recognition

Bioactive Materials

Yannong Dou¹  Yanxin Han²  Xinqi Gong³  Wei Jin⁴  Haimang Wang⁴  Xiaoyu Yu⁵  Yixin Wang⁶  Hongyu Zhang⁶  Yulong Sun⁷  Yue Dai⁷  Fangfu Ye⁷  Qiang Wang⁷ 

[1] Institute of Wenzhou, University of Chinese Academy of Sciences, Wenzhou, 325001, China;Lab of Soft Matter and Biological Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China;Department of Cardiovascular Medicine, Heart Failure Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 210009, China;Institute for Mathematical Sciences, Renmin University of China, Beijing, 100872, China;Lab of Soft Matter and Biological Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China;State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China;

关键词: Mesoporous silica nanoparticles;    Polyelectrolytes;    Lubrication;    Macrophage escape;    Drug delivery;   

DOI  :  

来源: DOAJ

【 摘 要 】

Accurate drug delivery to the lesion has been deliberated for several decades, but one important phenomenon is usually neglected that the immune system can prevent smooth transportation of nanomedicine. Although injection would reduce first-pass effect, macrophages in the blood can still recognize and phagocytose nanomedicine. Here we show that a lubricated nanocontainer, which is prepared based on polyelectrolytes and mesoporous silica nanoparticles, can accurately target muscarinic bioreceptor while escaping from the identification of macrophages. Through in vitro and in vivo studies, this nanocontainer, combining both immune escape and bioreceptor targeting, has greatly improved the drug bioavailability. Additionally, this nanocontainer shows good biocompatibility, and the targeted heart tissues and other important metabolic organs, such as liver and kidney, keep physiological structures and functions without the detection of side effects. Furthermore, the mechanism of immune escape for the developed nanocontainer has been investigated by lubrication test and molecular simulation. We anticipate that our study will establish a new perspective on the achievement of immune escape-based targeted drug delivery, which can provide a fundamental approach for the design of related biomaterials.

【 授权许可】

Unknown