Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control Fusarium graminearum and the Production of Mycotoxins

Molecules

Julien Gabaston¹  Pierre Waffo-Téguo¹  Nathalie Ferrer²  Marie-Noëlle Verdal-Bonnin²  Florence Richard-Forget²  Laetitia Pinson-Gadais²  Vessela Atanasova²  Mathilde Montibus³  Xavier Vitrac⁴  Anne Loron⁵  Véronique Coma⁵ 

[1] Faculté des Sciences Pharmaceutiques, Unité de Recherche Œnologie, EA 4577, USC 1366 INRAE, Equipe Molécules d’Intérêt Biologique-ISVV, Université de Bordeaux, F-33882 Villenave d’Ornon CEDEX, France;INRAE, UR1264 Mycology and Food Safety (MycSA), F-33882 Villenave d’Ornon, France;Institut technologique FCBA, Allée de Boutaut, BP 227, F-33028 Bordeaux CEDEX, France;Laboratoire Phenobio SAS, ZA Les Pins Verts, 22 Allée de Migelane, F-33650 Saucats, France;Laboratoire de Chimie des Polymères Organiques, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 16 Avenue Pey-Berland, F-33600 Pessac, France;

关键词: Fusarium graminearum;    type B trichothecenes;    natural extracts;    ecological strategies;    biofungicides;   

DOI  :  10.3390/molecules26020405

来源: DOAJ

【 摘 要 】

Fusarium graminearum is a fungal pathogen that can colonize small-grain cereals and maize and secrete type B trichothecene (TCTB) mycotoxins. The development of environmental-friendly strategies guaranteeing the safety of food and feed is a key challenge facing agriculture today. One of these strategies lies on the promising capacity of products issued from natural sources to counteract crop pests. In this work, the in vitro efficiency of sixteen extracts obtained from eight natural sources using subcritical water extraction at two temperatures was assessed against fungal growth and TCTB production by F. graminearum. Maritime pine sawdust extract was shown to be extremely efficient, leading to a significant inhibition of up to 89% of the fungal growth and up to 65% reduction of the mycotoxin production by F. graminearum. Liquid chromatography/mass spectrometry analysis of this active extract revealed the presence of three families of phenolics with a predominance of methylated compounds and suggested that the abundance of methylated structures, and therefore of hydrophobic compounds, could be a primary factor underpinning the activity of the maritime pine sawdust extract. Altogether, our data support that wood/forest by-products could be promising sources of bioactive compounds for controlling F. graminearum and its production of mycotoxins.

【 授权许可】

Unknown