期刊论文详细信息
Molecules
Screening of Wood/Forest and Vine By-Products as Sources of New Drugs for Sustainable Strategies to Control Fusarium graminearum and the Production of Mycotoxins
Julien Gabaston1  Pierre Waffo-Téguo1  Nathalie Ferrer2  Marie-Noëlle Verdal-Bonnin2  Florence Richard-Forget2  Laetitia Pinson-Gadais2  Vessela Atanasova2  Mathilde Montibus3  Xavier Vitrac4  Anne Loron5  Véronique Coma5 
[1] Faculté des Sciences Pharmaceutiques, Unité de Recherche Œnologie, EA 4577, USC 1366 INRAE, Equipe Molécules d’Intérêt Biologique-ISVV, Université de Bordeaux, F-33882 Villenave d’Ornon CEDEX, France;INRAE, UR1264 Mycology and Food Safety (MycSA), F-33882 Villenave d’Ornon, France;Institut technologique FCBA, Allée de Boutaut, BP 227, F-33028 Bordeaux CEDEX, France;Laboratoire Phenobio SAS, ZA Les Pins Verts, 22 Allée de Migelane, F-33650 Saucats, France;Laboratoire de Chimie des Polymères Organiques, Université de Bordeaux, CNRS, Bordeaux INP, UMR 5629, 16 Avenue Pey-Berland, F-33600 Pessac, France;
关键词: Fusarium graminearum;    type B trichothecenes;    natural extracts;    ecological strategies;    biofungicides;   
DOI  :  10.3390/molecules26020405
来源: DOAJ
【 摘 要 】

Fusarium graminearum is a fungal pathogen that can colonize small-grain cereals and maize and secrete type B trichothecene (TCTB) mycotoxins. The development of environmental-friendly strategies guaranteeing the safety of food and feed is a key challenge facing agriculture today. One of these strategies lies on the promising capacity of products issued from natural sources to counteract crop pests. In this work, the in vitro efficiency of sixteen extracts obtained from eight natural sources using subcritical water extraction at two temperatures was assessed against fungal growth and TCTB production by F. graminearum. Maritime pine sawdust extract was shown to be extremely efficient, leading to a significant inhibition of up to 89% of the fungal growth and up to 65% reduction of the mycotoxin production by F. graminearum. Liquid chromatography/mass spectrometry analysis of this active extract revealed the presence of three families of phenolics with a predominance of methylated compounds and suggested that the abundance of methylated structures, and therefore of hydrophobic compounds, could be a primary factor underpinning the activity of the maritime pine sawdust extract. Altogether, our data support that wood/forest by-products could be promising sources of bioactive compounds for controlling F. graminearum and its production of mycotoxins.

【 授权许可】

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