Hidden in Plants—A Review of the Anticancer Potential of the Solanaceae Family in In Vitro and In Vivo Studies

Cancers

Michał Bijak¹  Patricia Rijo²  Przemysław Sitarek³  Mattia Mori⁴  Karol Górski⁵  Anna Merecz-Sadowska⁶  Janusz Szemraj⁷  Tomasz Kowalczyk⁸  Janusz Piekarski⁹  Tomasz Śliwiński^1,10  Sophia Hatziantoniou^1,11 

[1] Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland;CBIOS—Research Center for Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, 1749-024 Lisbon, Portugal;Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland;Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy;Department of Clinical Pharmacology, Medical University of Lodz, 90-151 Lodz, Poland;Department of Computer Science in Economics, University of Lodz, 90-214 Lodz, Poland;Department of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland;Department of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland;Department of Surgical Oncology, Chair of Oncology, Medical University in Lodz, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, 93-513 Lodz, Poland;Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland;Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, University of Patras, 26504 Patras, Greece;

关键词: anticancer potential;    apoptosis;    cytotoxic effect;    in vitro and in vivo studies;    plant extracts;    pure compounds;   

DOI  :  10.3390/cancers14061455

来源: DOAJ

【 摘 要 】

Many of the anticancer agents that are currently in use demonstrate severe side effects and encounter increasing resistance from the target cancer cells. Thus, despite significant advances in cancer therapy in recent decades, there is still a need to discover and develop new, alternative anticancer agents. The plant kingdom contains a range of phytochemicals that play important roles in the prevention and treatment of many diseases. The Solanaceae family is widely used in the treatment of various diseases, including cancer, due to its bioactive ingredient content. The purpose of this literature review is to highlight the antitumour activity of Solanaceae extracts—single isolated compounds and nanoparticles with extracts—and their synergistic effect with chemotherapeutic agents in various in vitro and in vivo cancer models. In addition, the biological properties of many plants of the Solanaceae family have not yet been investigated, which represents a challenge and an opportunity for future anticancer therapy.

【 授权许可】

Unknown