Danggui Sini decoction protects against oxaliplatin-induced peripheral neuropathy in rats

Journal of Integrative Neuroscience

Zhen-Tao An¹  Guo-Li Wei²  Jie-Ge Huo²  Rong Ding²  Wu-Guang Lu²  Ji-Ping Zhu³  Zhan-Cheng Gu⁴  Yue Wang⁵ 

[1] 81 Hospital of People's Liberation Army, 210002, Nanjing, P. R. China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 210028, Nanjing, P. R. China;Affiliated Hospital of Nanjing University of Chinese Medicine, 210023, Nanjing, P. R. China;Haimen City Hospital of Traditional Chinese Medicine, 226100, Nantong, P. R. China;Nanjing University of Chinese Medicine, 210023, Nanjing, P. R. China;

关键词: oxaliplatin;    peripheral neuropathy;    neurotoxicity;    electrophysiology;   

DOI  :  10.31083/j.jin.2020.04.1154

来源: DOAJ

【 摘 要 】

The effects of Danggui Sini decoction on peripheral neuropathy in oxaliplatin-induced peripheral is established. The results indicated that Danggui Sini decoction treatment significantly reduced the current amplitude of dorsal root ganglia cells undergoing agonists stimuli compared to the model-dorsal root ganglia group (P Danggui Sini decoction treatment significantly inhibited the inflammatory response of dorsal root ganglia cells compared to the model-dorsal root ganglia group (P Danggui Sini decoction treatment significantly enhanced the amounts of Nissl bodies in dorsal root ganglia cells compared to the Model-dorsal root ganglia group (P Danggui Sini decoction treatment improved ultra-microstructures of dorsal root ganglia cells. In conclusion, Danggui Sini decoction protected against neurotoxicity of oxaliplatin-induced peripheral neuropathy in rats by suppressing inflammatory lesions, improving ultra-microstructures, and enhancing amounts of Nissl bodies.

【 授权许可】

Unknown