Repeated Administration of Amitriptyline Reduces Oxaliplatin-Induced Mechanical Allodynia in Rats

Journal of Pharmacological Sciences

Masafumi Shirahama¹  Soichiro Ushio¹  Hikaru Sada¹  Nobuaki Egashira¹  Ryozo Oishi¹  Takehiro Kawashiri¹ 

[1] Department of Pharmacy, Kyushu University Hospital, Japan

关键词: oxaliplatin;    amitriptyline;    peripheral neuropathy;   

DOI  :  10.1254/jphs.12006SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(17)Cited-By(8)Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies in patients. Amitriptyline has widely been used in patients with painful neuropathy. In this study, we investigated the effect of amitriptyline on the oxaliplatin-induced neuropathy in rats. Repeated administration of amitriptyline (5 and 10 mg/kg, p.o., once a day) reduced the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia and reversed the oxaliplatin-induced increase in the expression of NR2B protein and mRNA in rat spinal cord. These results suggest that amitriptyline is useful for the treatment of oxaliplatin-induced neuropathy clinically.

【 授权许可】

Unknown