Synthesis of the Marine Bromotyrosine Psammaplin F and Crystal Structure of a Psammaplin A Analogue

Molecules

关键词: psammaplin F;    marine bromotyrosine;    Cleland’s reagent;    total synthesis;    X-ray crystal structure;   

DOI  :  10.3390/molecules15128784

来源: DOAJ

【 摘 要 】

Psammaplin F, an unsymmetrical disulfide bromotyrosine, was isolated from the sponge Pseudoceratina purpurea in 2003. We reported here the first total synthesis of psammaplin F in 12% overall yield by employing Cleland’s reagent reduction as key step. The longest linear synthetic sequence starting from 3-bromo-4-hydroxybenzaldehyde and hydantoin was seven steps. In addition, a detailed X-ray crystal structure analysis of psammaplin A analogue 8b is given for the first time.

【 授权许可】

Unknown