Regulation of Mitochondrial Function by the Actin Cytoskeleton

Frontiers in Cell and Developmental Biology

Miguel A. Martín¹  Joaquín Arenas¹  Cristina Ugalde¹  Ana Peñas²  María Illescas² 

[1] Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain;Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain;

关键词: mitochondria;    actin cytoskeleton;    OXPHOS system;    gelsolin;    mitochondrial disease;   

DOI  :  10.3389/fcell.2021.795838

来源: DOAJ

【 摘 要 】

The regulatory role of actin cytoskeleton on mitochondrial function is a growing research field, but the underlying molecular mechanisms remain poorly understood. Specific actin-binding proteins (ABPs), such as Gelsolin, have also been shown to participate in the pathophysiology of mitochondrial OXPHOS disorders through yet to be defined mechanisms. In this mini-review, we will summarize the experimental evidence supporting the fundamental roles of actin cytoskeleton and ABPs on mitochondrial trafficking, dynamics, biogenesis, metabolism and apoptosis, with a particular focus on Gelsolin involvement in mitochondrial disorders. The functional interplay between the actin cytoskeleton, ABPs and mitochondrial membranes for the regulation of cellular homeostasis thus emerges as a new exciting field for future research and therapeutic approaches.

【 授权许可】

Unknown