Imaging features associated with survival outcomes among colorectal cancer patients with and without KRAS mutation

The Egyptian Journal of Radiology and Nuclear Medicine

Chaiwat Apivatanasiri¹  Prakasit Sa-ngaimwibool¹  Kulyada Somsap²  Julaluck Promsorn²  Payia Chadbunchachai²  Rita Maria Lahoud³  Mukesh Harisinghani³  Krisada Paonariang⁴ 

[1] Department of Pathology, Faculty of Medicine, Khon Kaen University;Department of Radiology, Faculty of Medicine, Khon Kaen University;Department of Radiology, Massachusetts General Hospital, Harvard Medical School;Department of Surgery, Faculty of Medicine, Khon Kaen University;

关键词: Colorectal cancer;    KRAS mutation;    CT;    MRI;   

DOI  :  10.1186/s43055-020-00393-x

来源: DOAJ

【 摘 要 】

Abstract Background Mutations in Kirsten rat sarcoma proto-oncogene (KRAS) have been shown to be associated with advanced-stage colorectal cancer (CRC), negative disease outcomes, and poor response to treatment. The purpose of this study was to investigate which CT features are biomarkers for KRAS gene mutation and impact the survival outcomes of colorectal cancer patients. Results Of the 113 CRC patients included in the study, 46 had KRAS mutations (40.71%) and 67 had no mutations (59.29%). Regional lymph node necrosis was the only imaging feature significantly associated with KRAS mutation (P = 0.011). Higher T staging and liver, lung, and distant metastasis were prognostic factors for CRC (P = 0.014, P < 0.001, P = 0.022, P < 0.001, respectively). There were no significant differences in overall survival between patients with KRAS mutations and those without (P = 0.159). However, in patients with no KRAS mutation, those with CRC on the left side had a significantly higher rate of survival than those with CRC on the right (P = 0.005). Conclusion Regional lymph node necrosis may be an imaging biomarker of CRC with KRAS mutation, possibly indicating poor prognosis.

【 授权许可】

Unknown