Gammaherpesvirus Infections in Cattle in Europe

Viruses

Ernst Groβmann¹  Mohammed Al-Saadi²  James P. Stewart²  Martina Dettwiler³  Eleni Michalopoulou⁴  Koen Chiers⁵  Heli Nordgren⁶  Ranieri Verin⁷  Kernt Köhler⁸  Michael Suntz⁹  Giuliana Rosato^1,10  Andres Ruiz Subira^1,10  Anja Kipar^1,10 

[1] Aulendorf State Veterinary Diagnostic Centre, Löwenbreitestrasse 18/20, 88326 Aulendorf, Germany;Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK;Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, 3012 Bern, Switzerland;Department of Livestock and One Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston CH64 7TE, UK;Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Agnes Sjöbergin katu 2, 00014 Helsinki, Finland;Department of Veterinary Pathology and Public Health, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston CH64 7TE, UK;Faculty of Veterinary Medicine, Institute of Veterinary Pathology, Justus-Liebig-University Giessen, Frankfurter Strasse 96, 35390 Giessen, Germany;State Institute for Chemical and Veterinary Analysis Freiburg, Bissierstrasse 5, 79114 Freiburg im Breisgau, Germany;Vetsuisse Faculty, Institute of Veterinary Pathology, University of Zurich, Winterthurerstrasse 268, 8057 Zurich, Switzerland;

关键词: BoHV-6;    commensal;    gammaherpesvirus;    qPCR;    European cattle;   

DOI  :  10.3390/v13122337

来源: DOAJ

【 摘 要 】

The genus Macavirus, subfamily Gammaherpesvirinae, comprises ungulate viruses that infect domestic and wild ruminants and swine. They cause asymptomatic latent infections in reservoir hosts and malignant catarrhal fever in susceptible species. Lung, spleen, bronchial lymph node, and tongue were collected from 448 cattle (348 necropsied, 100 slaughtered) in Switzerland, United Kingdom, Finland, Belgium, and Germany to determine their infection with bovine herpesvirus-6 (BoHV-6) and gammaherpesviruses of other ruminants, i.e., ovine herpesvirus-1 and -2, caprine herpesvirus-2, and bison lymphotropic herpesvirus, using quantitative PCR. Only BoHV-6 was detected, with an overall frequency of 32%, ranging between 22% and 42% in the different countries. Infection was detected across all ages, from one day after birth, and was positively correlated with age. There was no evidence of an association with specific disease processes. In positive animals, BoHV-6 was detected in all organs with high frequency, consistently in the lungs or spleen. Viral loads varied substantially. In BoHV-6-positive gravid cows, organs of fetuses tested negative for infection, indicating that the virus is not vertically transmitted. Our results confirm previous data indicating that BoHV-6 is a commensal of domestic cattle not associated with disease processes and confirm that infections with other macaviruses are rare and sporadic.

【 授权许可】

Unknown