Challenges and Improvements of Novel Therapies for Ischemic Stroke

Frontiers in Pharmacology

Bo Yang¹  Jiajia Wang¹  Lijun Yang¹  Qinjie Weng²  Qiaojun He²  Jing Qian³ 

[1] Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China;Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;Zhejiang Center for Drug and Cosmetic Evaluation, Hangzhou, China;

关键词: ischemic stroke;    neuroprotective agent;    advances and limitations;    structure transformation;    combination therapy;   

DOI  :  10.3389/fphar.2021.721156

来源: DOAJ

【 摘 要 】

Stroke is the third most common disease all over the world, which is regarded as a hotspot in medical research because of its high mortality and morbidity. Stroke, especially ischemic stroke, causes severe neural cell death, and no effective therapy is currently available for neuroregeneration after stroke. Although many therapies have been shown to be effective in preclinical studies of ischemic stroke, almost none of them passed clinical trials, and the reasons for most failures have not been well identified. In this review, we focus on several novel methods, such as traditional Chinese medicine, stem cell therapy, and exosomes that have not been used for ischemic stroke till recent decades. We summarize the proposed basic mechanisms underlying these therapies and related clinical results, discussing advantages and current limitations for each therapy emphatically. Based on the limitations such as side effects, narrow therapeutic window, and less accumulation at the injury region, structure transformation and drug combination are subsequently applied, providing a deep understanding to develop effective treatment strategies for ischemic stroke in the near future.

【 授权许可】

Unknown