Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy

International Journal of Molecular Sciences

Ping-Fang Chiang¹  Cheng-Liang Peng¹  Ying-Hsia Shih¹  Chun-Tang Chen¹  Ming-Cheng Chang¹ 

[1] Isotope Application Division, Institute of Nuclear Energy Research, P.O. Box 3-27, Longtan, Taoyuan 32526, Taiwan;

关键词: multi-modality;    cyanine dye;    near-infrared fluorescence imaging;    nuclear imaging;    photothermal therapy;    targeted radionuclide therapy;   

DOI  :  10.3390/ijms222212214

来源: DOAJ

【 摘 要 】

Cancer is one of the leading causes of death in the world. A cancer-targeted multifunctional probe labeled with the radionuclide has been developed to provide multi-modalities for NIR fluorescence and nuclear imaging (PET, SPECT), for photothermal therapy (PTT), and targeted radionuclide therapy of cancer. In this study, synthesis, characterization, in vitro, and in vivo biological evaluation of the cyanine-based probe (DOTA-NIR790) were demonstrated. The use of cyanine dyes for the selective accumulation of cancer cells were used to achieve the characteristics of tumor markers. Therefore, all kinds of organ tumors can be targeted for diagnosis and treatment. The DOTA-NIR790 labeled with lutetium-111 could detect original or metastatic tumors by using SPECT imaging and quantify tumor accumulation. The β-emission of ¹⁷⁷Lu-DOTA-NIR790 can be used for targeted radionuclide therapy of tumors. The DOTA-NIR790 enabled imaging by NIR fluorescence and by nuclear imaging (SPECT) to monitor in real-time the tumor accumulation and the situation of cancer therapy, and to guide the surgery or the photothermal therapy of the tumor. The radionuclide-labeled heptamethine cyanine based probe (DOTA-NIR790) offers multifunctional modalities for imaging and therapies of cancer.

【 授权许可】

Unknown