Cardiac Sarcoidosis Is Uncommon in Patients with Isolated Sarcoid Uveitis: Outcome of 294 Cases

Journal of Clinical Medicine

Pierre-Yves Courand¹  Cécile-Audrey Durel²  Arnaud Hot³  Laurent Perard⁴  Mael Richard⁵  Mathieu Gerfaud-Valentin⁵  Pascal Seve⁵  Yvan Jamilloux⁵  Isabelle Durieu⁶  Carole Burillon⁷  Laurent Kodjikian⁸ 

[1]Department of Cardiology, Hôpital de la Croix-Rousse et Hôpital Lyon Sud, Hospices Civils de Lyon, Creatis, Université Claude Bernard Lyon 1, 69004 Lyon, France

[2]Department of Internal Medicine, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69003 Lyon, France

[3]Department of Internal Medicine, Hôpital Edouard Herriot, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69003 Lyon, France

[4]Department of Internal Medicine, Hôpital Saint-Joseph Saint-Luc, 69007 Lyon, France

[5]Department of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69004 Lyon, France

[6]Department of Internal and Vascular Medicine, Hôpital Lyon Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69003 Lyon, France

[7]Department of Ophthalmology, Hôpital Edouard Herriot, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69003 Lyon, France

[8]Department of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69004 Lyon, France

关键词: sarcoidosis;    uveitis;    cardiac sarcoidosis;   

DOI  :  10.3390/jcm10102146

来源: DOAJ

【 摘 要 】

Recently, concerns have been raised about an increased risk of cardiac sarcoidosis in patients with sarcoid uveitis. While cardiac sarcoidosis has a high mortality burden, there is still a lack of precise data on this association. The objective of this study is to describe the frequency and type of cardiac complications associated with sarcoidosis of a large cohort of patients with sarcoid uveitis. We analyzed the cardiac outcomes of a monocentric retrospective cohort of consecutive adults with a diagnosis of sarcoid uveitis between January 2004 and March 2020 in a tertiary French university hospital. A total of 294 patients with a final diagnosis of sarcoid uveitis were included. At final follow-up, seven (2.4%) patients of the cohort had cardiac sarcoidosis. Cardiac sarcoidosis was more frequent among patients with previously reported systemic sarcoidosis (p = 0.008). The prevalence of cardiac sarcoidosis among patients with sarcoid uveitis is low, but patients with previously diagnosed sarcoidosis or those who develop systemic sarcoidosis during follow-up appear to be at increased risk.

【 授权许可】

Unknown