Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure

International Journal of Environmental Research and Public Health

Scarlett Murphy¹  KerryM. Hena¹  Angeliki Kazeros¹  Joan Reibman¹  Yian Zhang²  Yongzhao Shao² 

[1] Department of Medicine, New York University, New York, NY 10016, USA;Department of Population Health and Environmental Medicine, New York University, New York, NY 10016, USA;

关键词: sarcoidosis;    World Trade Center (WTC);    Scadding stage;    lung function;    severe lung disease;    extrathoracic sarcoidosis;    cardiac sarcoidosis;   

DOI  :  10.3390/ijerph16071291

来源: DOAJ

【 摘 要 】

Background: Sarcoidosis is a granulomatous disease involving intrathoracic and extrathoracic organs. Genetic and environmental factors, such as exposure to World-Trade Center (WTC) dust after 9/11, may play a role in clinical presentation. Characterization of sarcoidosis in community members with exposure to the WTC dust can provide further insight into the relationship between environmental exposure and sarcoidosis. Methods: Patients with documented sarcoidosis were identified in the WTC Environmental Health Center (EHC), a treatment program for community members. Demographic and clinical data were collected from standardized questionnaires and chart review. Organ involvement was assessed with a standard instrument. Results: Among patients in the WTC EHC, 87 were identified with sarcoidosis after 9/11. Sarcoidosis cases were more likely African-American, local workers, and had more respiratory symptoms, compared with non-sarcoidosis WTC EHC patients. Many (46%) had ≥ Scadding stage 3 on chest imaging, and had reduced lung function measures. Extrathoracic involvement was identified in 33/87 (38%) with a diversity of organs involved. Conclusions: WTC-exposed sarcoidosis in community members is often characterized by severe pulmonary disease and a high rate of diverse extrathoracic involvement. Further analysis is required to characterize the course of disease progression or resolution.

【 授权许可】

Unknown