Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D3 in Fetal Lung Adenocarcinoma: Case Report

JTO Clinical and Research Reports

Mistuaki Ishida, MD, PhD¹  Takahiro Utsumi, MD²  Koji Tsuta, MD, PhD²  Tomohiro Murakawa, MD, PhD²  Makiko Kusabe, MD³  Hiroyasu Tsukaguchi, MD, PhD³  Takanobu Imada, MD, PhD⁴  Hiroaki Kurokawa, MD, PhD⁵  Hiroshi Matsui, MD⁶  Tomohito Saito, MD, PhD⁶  Natsumi Maru, MD⁶  Yohei Taniguchi, MD, PhD⁶  Takayasu Kurata, MD, PhD⁶ 

[1] Corresponding author. Address for correspondence: Tomohito Saito, MD, PhD, Department of Thoracic Surgery, Kansai Medical University Hospital, 2-3-1, Shinmachi, Hirakata, Osaka 573-1191, Japan.;Department of Nephrology, Kansai Medical University Hospital, Osaka, Japan;Department of Pathology, Kansai Medical University Hospital, Osaka, Japan;Department of Radiology, Kansai Medical University Hospital, Osaka, Japan;Department of Thoracic Oncology, Kansai Medical University Hospital, Osaka, Japan;Department of Thoracic Surgery, Kansai Medical University Hospital, Osaka, Japan;

关键词: Hypercalcemia of malignancy;    Lung cancer;    1,25-Dihydroxyvitamin D3;    Case report;   

DOI  :  

来源: DOAJ

【 摘 要 】

Hypercalcemia is a common electrolyte abnormality in malignancy and is largely caused by activation of parathyroid hormone (PTH) pathways. We report the case of a 76-year-old man with hypercalcemia primarily owing to 1,25-dihydroxyvitamin D3 overproduction from a high-grade fetal lung adenocarcinoma. Histologically, the tumor itself and tumor-adjacent macrophages were positive for the CYP27B1 protein, a key enzyme that generates 1,25-dihydroxyvitamin D3. Suppression was observed in serum PTH and PTH-related hormone levels, suggesting hypercalcemia is independent of the PTH pathway. Serum calcium level returned to normal after surgical resection of the lung cancer, supporting extrarenal overproduction of 1,25-dihydroxyvitamin D3 elicited by the tumors is the cause of hypercalcemia in this patient.

【 授权许可】

Unknown