Polysaccharide extracted from Enteromorpha ameliorates Cisplastin-induced small intestine injury in mice

Journal of Functional Foods

Dong Shang¹  Yi Xin²  Xinxiu Ren²  Yaser Gamallat²  Pingkun Liu²  Lei Liu³ 

[1] Corresponding authors.;Department of Biotechnology, Dalian Medical University, Dalian, China;Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China;

关键词: Cisplatin (DDP);    Polysaccharide Extracted from Enteromorpha (PEP);    Intestinal microbiota;    Escherichia-Shigella;   

DOI  :  

来源: DOAJ

【 摘 要 】

Cisplatin is a commonly used drug against solid tumors. However, it can cause cell death in rapidly dividing intestinal epithelial cells. Enteromorpha (EP), an edible marine alga found in eastern China, and its polysaccharide fraction (PEP), can relieve constipation and modulate the intestinal microbiota. The aim of our study was to investigate the possible role of PEP in preventing cisplatin induced intestinal damage and gut microbiota imbalance in a mouse model. Cisplatin disturbed the intestinal microbiota and damaged the intestinal barriers. PEP treatment prior to cisplatin injection ameliorated these injuries and restored the gut microbial composition. We also analyzed the diversity of the fecal bacterial population by 16S DNA sequencing, and found a high abundance of the Escherichia – Shigella genera in the cisplatin treated mice. In conclusion, our results indicate that PEP is a powerful natural product that can protect against the gastrointestinal side effects of cisplatin.

【 授权许可】

Unknown