Antimicrobial Properties of Apis mellifera’s Bee Venom

Toxins

Lei Chen¹  Aida Abd El-Wahed²  Nermeen Yosri²  Moustafa Moustafa³  Saleh Al-Mousawi³  Shaden Khalifa⁴  Alfi Khatib⁵  SyedGhulam Musharraf⁶  Hesham El-Seedi⁷  Xiaobo Zou⁸  Zhiming Guo⁸ 

[1] College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China;Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt;Department of Chemistry, Faculty of Science, University of Kuwait, Safat 13060, Kuwait;Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91 Stockholm, Sweden;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang 25200, Malaysia;H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan;International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China;School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China;

关键词: bee venom;    antimicrobial properties;    melittin;    apamin;    phospholipase A2 (PLA2);   

DOI  :  10.3390/toxins12070451

来源: DOAJ

【 摘 要 】

Bee venom (BV) is a rich source of secondary metabolites from honeybees (Apis mellifera L.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds contribute to the venom’s observed biological functions as per its anti-inflammatory and anticancer effects. The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The synergistic therapeutic interactions of BV with antibiotics has been reported. The synergistic effect contributes to a decrease in the loading and maintenance dosage, a decrease in the side effects of chemotherapy, and a decrease in drug resistance. To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of this review is to address the antimicrobial properties of BV and its compounds.

【 授权许可】

Unknown