Estimating prevalence of chronic obstructive pulmonary disease in the Southern Cone of Latin America: how different spirometric criteria may affect disease burden and health policies

BMC Pulmonary Medicine

Pamela Serón¹  Fernando Lanas¹  Chung-Shiuan Chen²  Jiang He²  Jacqueline Ponzo³  Allison Lee⁴  Edgardo Sobrino⁵  Vilma E. Irazola⁵  Laura Gutierrez⁵  Adolfo L. Rubinstein⁶  Matías Calandrelli⁷  Nora Mores⁸ 

[1] CIGES, Faculty of Medicine of the Universidad de la Frontera;Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine;Department of Family and Community Medicine, Universidad de la República;Icahn School of Medicine at Mount Sinai, Division of Pulmonary, Critical Care and Sleep Medicine;Institute for Clinical Effectiveness and Health Policy;National Ministry of Health;Sanatorio San Carlos;Secretaría de Salud, Municipalidad de Marcos Paz;

关键词: Chronic obstructive pulmonary disease;    Prevalence;    Fixed ratio;    Lower limit normal;    Risk factors;    South America;   

DOI  :  10.1186/s12890-017-0537-9

来源: DOAJ

【 摘 要 】

Abstract Background Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. The study aimed to determine and compare the prevalence of COPD in the general population aged 45-74 years old according to fixed ratio and lower limit of normal (LLN) thresholds in four cities in the Southern Cone of Latin America. Methods The Pulmonary Risk in South America (PRISA) study used a 4-stage stratified sampling method to select 5814 participants from 4 cities in the Southern Cone of Latin America (Bariloche and Marcos Paz, Argentina; Temuco, Chile; and Pando-Barros Blancos, Uruguay). Data on demographic information, medical history, risk factors, pre-bronchodilator and post-bronchodilator spirometry were obtained using a standard protocol. According to GOLD, COPD was defined as a post-bronchodilator ratio of forced expiratory volume in one second (FEV1) over forced vital capacity (FVC) less than 70%. The LLN threshold was defined as the lower fifth percentile for predicted FEV1/FVC, and was evaluated as an alternative COPD definition. Results Overall COPD prevalence was 9.3% (95% CI 8.4, 10.2%), and men had a higher prevalence [11.8% (95% CI 10.3, 13.3%)] than women [7.3% (95% CI 6.2, 8.3%)] with the fixed ratio. Overall COPD prevalence using LLN was 4.7% (95% CI 4.1, 5.3%), higher in men: 5.8% (95% CI 4.7, 6.8%) than women: 3.9% (95% CI 3.1, 4.7%). COPD prevalence was significantly higher among those who were older, had

【 授权许可】

Unknown