Plasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer’s disease

Alzheimer’s Research & Therapy

Bang-Hung Yang¹  Chiung-Chih Chang²  Chin-Chang Huang³  Yi-Chung Lee⁴  Po-Chen Lin⁴  Pei-Ning Wang⁵  Szu-Ying Lin⁶  Tzu-Chen Yen⁷  Ing-Tsung Hsiao⁷  Kun-Ju Lin⁷  Wen-Sheng Huang⁸ 

[1] Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University;Department of Neurology, Kaohsiung Chang Gung Memorial Hospital;Department of Neurology, Linkou Chang Gung Memorial Hospital and University;Department of Neurology, Neurological Institute, Taipei Veterans General Hospital;Department of Neurology, School of Medicine, National Yang-Ming University;Department of Neurology, Taipei Municipal Gan-Dau Hospital;Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital;Department of Nuclear Medicine, Taipei Veterans General Hospital;

关键词: Amyloid PET;    APOE;    Plasma Aβ;    Biomarkers;    MCI;    AD;   

DOI  :  10.1186/s13195-019-0566-0

来源: DOAJ

【 摘 要 】

Abstract Introduction Due to the high cost and high failure rate of ascertaining amyloid positron emission tomography positivity (PET+) in patients with earlier stage Alzheimer’s disease (AD), an effective pre-screening tool for amyloid PET scans is needed. Methods Patients with mild cognitive impairment (n = 33, 24.2% PET+, 42% females, age 74.4 ± 7.5, MMSE 26.8 ± 1.9) and mild dementia (n = 19, 63.6% PET+, 36.3% females, age 73.0 ± 9.3, MMSE 22.6 ± 2.0) were recruited. Amyloid PET imaging, Apolipoprotein E (APOE) genotyping, and plasma amyloid β (Aβ)1–40, Aβ1–42, and total tau protein quantification by immunomagnetic reduction (IMR) method were performed. Receiver operating characteristics (ROC) analysis and Youden’s index were performed to identify possible cut-off points, clinical sensitivities/specificities, and areas under the curve (AUCs). Results Amyloid PET+ participants had lower plasma Aβ1–42 levels than amyloid PET-negative (PET−) subjects. APOE ε4 carriers had higher plasma Aβ1–42 than non-carriers. We developed an algorithm involving the combination of plasma Aβ1–42 and APOE genotyping. The success rate for detecting amyloid PET+ patients effectively increased from 42.3 to 70.4% among clinically suspected MCI and mild dementia patients. Conclusions Our results demonstrate the possibility of utilizing APOE genotypes in combination with plasma Aβ1–42 levels as a pre-screening tool for predicting the positivity of amyloid PET findings in early stage dementia patients.

【 授权许可】

Unknown