Low concentrations of Lactobacillus rhamnosus GG (Yoba®) are safe in male Drosophila melanogaster

BMC Research Notes

Dickson Stuart Tayebwa¹  Andrew Tamale¹  Fred Ssempijja²  Isaac Echoru²  Oscar Hilary Asiimwe³  Lisa Nkatha Micheni⁴  Sarah Kemuma Onkoba⁴  Ibrahim Ntulume⁴  Josephine Kasolo⁵  Emmanuel Tiyo Ayikobua⁶  Joy Suubo⁶  Keneth Iceland Kasozi⁶  Ejike Daniel Eze⁶  Muhamudu Kalange⁶  Aisha Bukenya⁷ 

[1] College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University;Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University Western Campus;Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University Western Campus;Department of Microbiology, Faculty of Biomedical Sciences, Kampala International University Western Campus;Department of Physiology, College of Health Sciences, Makerere University;Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus;School of Pharmacy, Kampala International University Western Campus;

关键词: Probiotics;    Yoba for life;    Nutritional toxicology;    Yoghurt;    Food supplements;    Catalase;   

DOI  :  10.1186/s13104-019-4297-x

来源: DOAJ

【 摘 要 】

Abstract Objective The purpose of the study was to generate information on the safety of probiotics, thus the study objectives were to evaluate the effects of Yoba® on basic physiochemical properties. The study assessed male w 1118 Drosophila melanogaster which were provided food supplemented with Yoba® at 1%, 3%, 6%, and 12% on motor function, total protein, catalase activity, and hydrogen peroxide scavenging activity and lifespan. Results Yoba® at high concentration (≥ 6%) increased locomotor activity in Drosophila melanogaster, however, total protein, catalase, and hydrogen peroxide scavenging activity were significantly higher at 1% Yoba® compared to 3%, 6%, and 12% Yoba®. Yoba consumed at 1% was associated with greater physiological benefits in Drosophila melanogaster. Findings in the study offer a rationale for the consumption of Yoba® at 1% in humans as is currently being promoted by the Yoba for Life consortium, however, high concentrations of Yoba® would disrupt physiological function as shown by this study.

【 授权许可】

Unknown