Low concentrations of Lactobacillus rhamnosus GG (Yoba®) are safe in male Drosophila melanogaster

BMC Research Notes

Andrew Tamale¹  Dickson Stuart Tayebwa¹  Josephine Kasolo²  Isaac Echoru³  Fred Ssempijja³  Oscar Hilary Asiimwe⁴  Ibrahim Ntulume⁵  Lisa Nkatha Micheni⁵  Sarah Kemuma Onkoba⁵  Keneth Iceland Kasozi⁶  Joy Suubo⁶  Muhamudu Kalange⁶  Emmanuel Tiyo Ayikobua⁶  Ejike Daniel Eze⁷  Aisha Bukenya⁸ 

[1] 0000 0004 0620 0548, grid.11194.3c, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, Box 7062, Kampala, Uganda;0000 0004 0620 0548, grid.11194.3c, Department of Physiology, College of Health Sciences, Makerere University, Box 7062, Kampala, Uganda;0000 0004 0648 1247, grid.440478.b, Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda;0000 0004 0648 1247, grid.440478.b, Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda;0000 0004 0648 1247, grid.440478.b, Department of Microbiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda;0000 0004 0648 1247, grid.440478.b, Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda;0000 0004 0648 1247, grid.440478.b, Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71, Bushenyi, Uganda;grid.449527.9, Department of Biomedical Sciences, School of Medicine, Kabale University, Kabale, Uganda;0000 0004 0648 1247, grid.440478.b, School of Pharmacy, Kampala International University Western Campus, Box 71, Bushenyi, Uganda;

关键词: Probiotics;    Yoba for life;    Nutritional toxicology;    Yoghurt;    Food supplements;    Catalase;    Hydrogen peroxide scavenging;    Aging;   

DOI  :  10.1186/s13104-019-4297-x

来源: publisher

【 摘 要 】

ObjectiveThe purpose of the study was to generate information on the safety of probiotics, thus the study objectives were to evaluate the effects of Yoba® on basic physiochemical properties. The study assessed male w1118Drosophila melanogaster which were provided food supplemented with Yoba® at 1%, 3%, 6%, and 12% on motor function, total protein, catalase activity, and hydrogen peroxide scavenging activity and lifespan.ResultsYoba® at high concentration (≥ 6%) increased locomotor activity in Drosophila melanogaster, however, total protein, catalase, and hydrogen peroxide scavenging activity were significantly higher at 1% Yoba® compared to 3%, 6%, and 12% Yoba®. Yoba consumed at 1% was associated with greater physiological benefits in Drosophila melanogaster. Findings in the study offer a rationale for the consumption of Yoba® at 1% in humans as is currently being promoted by the Yoba for Life consortium, however, high concentrations of Yoba® would disrupt physiological function as shown by this study.

【 授权许可】

CC BY