The First Case of Ischemia-Free Kidney Transplantation in Humans

Frontiers in Medicine

Liqiu Mo¹  Otto B. van Leeuwen²  Qiang Zhao³  Yitao Zheng³  Chuanbao Chen³  Shanzhou Huang³  Zhiyong Guo³  Xingyuan Jiao³  Xiaopeng Yuan³  Zebin Zhu³  Ming Han³  Linhe Wang³  Xiaoshun He³  Guodong Chen³  Changxi Wang³  Zhiheng Zhang³  Yunhua Tang³  Xiaoping Wang³  Xianchang Li⁵  Jun Cui⁶  Jiefu Huang⁸ 

[1] Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands;Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, China;Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China;Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX, United States;MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China;Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;Peking Union Medical College Hospital, Beijing, China;

关键词: kidney transplantation;    ischemia-reperfusion injury;    normothermic machine perfusion;    ischemia-free kidney transplantation;    ischemia-free organ transplantation;   

DOI  :  10.3389/fmed.2019.00276

来源: DOAJ

【 摘 要 】

Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT).Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion.Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery.Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.

【 授权许可】

Unknown