The First Case of Ischemia-Free Kidney Transplantation in Humans

Frontiers in Medicine

article

Xiaoshun He¹  Shanzhou Huang¹  Linhe Wang¹  Otto B. van Leeuwen⁴  Xiaoping Wang¹  Chuanbao Chen¹  Liqiu Mo⁵  Xingyuan Jiao¹  Xianchang Li¹  Changxi Wang¹  Jiefu Huang¹  Guodong Chen¹  Jun Cui⁸  Zhiyong Guo¹  Zebin Zhu¹  Zhiheng Zhang¹  Xiaopeng Yuan¹  Ming Han¹  Qiang Zhao¹  Yitao Zheng¹  Yunhua Tang¹ 

[1] Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University;Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology;Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation);Department of Surgery, University Medical Center Groningen, University of Groningen;Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University;Immunobiology and Transplant Science Center, Houston Methodist Research Institute, United States;Peking Union Medical College Hospital;MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University

关键词: kidney transplantation;    ischemia-reperfusion injury;    normothermic machine perfusion;    ischemia-free kidney transplantation;    ischemia-free organ transplantation;   

DOI  :  10.3389/fmed.2019.00276

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT). Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion. Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery. Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.

【 授权许可】

CC BY