Prevalence and Risk Factors for Anti-SARS-CoV-2 Antibody in Chronic Kidney Disease (Dialysis Independent and Not)

Pathogens

Giovanna Lunghi¹  Sara Uceda Renteria¹  Ferruccio Ceriotti¹  Carlo Maria Alfieri²  Mariana Siddi²  Emanuele Grimaldi²  Paolo Molinari²  Elisa Colombo²  Fabrizio Fabrizi²  Giuseppe Castellano²  Marianna Tangredi² 

[1] Clinical Laboratory, Maggiore Policlinico Hospital and IRCCS Ca’ Granda Foundation, 20122 Milano, Italy;Division of Nephrology, Dialysis and Kidney Transplant, Maggiore Policlinico Hospital and IRCCS Ca’ Granda Foundation, 20122 Milano, Italy;

关键词: chronic kidney disease;    COVID-19;    dialysis;    epidemiology;    SARS-CoV-2;    serology;   

DOI  :  10.3390/pathogens11050572

来源: DOAJ

【 摘 要 】

Background: The evidence in the medical literature regarding the prevalence of antibody towards SARS-CoV-2 in patients with chronic kidney disease is limited, particularly among those at the pre-dialysis stage. Aim: We have prospectively performed a cohort study at a third-level university hospital to evaluate frequency and risk factors for anti-SARS-CoV-2-positive serology among chronic kidney disease patients. Methods: We have tested a cohort of consecutive outpatients with chronic kidney disease on regular follow-up at a major metropolitan hospital, during the SARS-CoV-2 outbreak in Italy. We adopted an enzyme immunoassay for the assessment of IgM/IgG antibodies to SARS-CoV-2 in human serum or plasma (DIA.PRO COVID-19 Serological Assay); the assay detects antibodies against Spike (1/2) and Nucleocapsid proteins of the SARS-CoV-2 genome. Results: There were 199 (65.8%) out of 302 patients with dialysis-independent CKD; 2 patients were anti-SARS-CoV-2 IgM antibody positive, 23 were anti-SARS-CoV-2 IgM/IgG positive and 37 had detectable anti-SARS-CoV-2 IgG antibody in serum. The prevalence of anti-SARS-CoV-2 IgG was 20.5% (60/302). All patients positive for anti-SARS-CoV-2 antibody tested negative by nasopharyngeal swab. A significant and independent relationship between anti-SARS-CoV-2-positive serologic status and serum albumin (a marker of nutritional status) was observed (p < 0.046). The prevalence of anti-SARS-CoV-2 antibody was greater in CKD than in control populations (health care workers and blood donors) attending the hospital a few months before the current study (7.6% and 5.2%, respectively). Conclusions: The great prevalence of anti-SARS-CoV-2 antibody in our study group could be, at least partially, explained with the fact that our patients were living in Milan, an area severely hit by SARS-CoV-2 infection. It seems that a poor nutritional status supports the acquisition of SARS-CoV-2 antibody in CKD patients. Clinical studies to understand the mechanisms responsible for the high frequency of SARS-CoV-2 infection are under way.

【 授权许可】

Unknown