Scavenger Receptor Structure and Function in Healthand Disease

Cells

Izma Abdul Zani¹  Nadeem A. Mughal¹  Sam L. Stephen¹  Sreenivasan Ponnambalam¹  Stephen B. Wheatcroft²  Shervanthi Homer-Vanniasinkam³  David Russell³ 

[1] Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK;Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK;Leeds Vascular Institute, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK;

关键词: Scavenger receptor;    Oxidized LDL particle;    Atherosclerosis;    Signal transduction;   

DOI  :  10.3390/cells4020178

来源: DOAJ

【 摘 要 】

Scavenger receptors (SRs) are a ‘superfamily’ of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous proteins and pathogens. New family of SRs and their properties have been identified in recent years, and have now been classified into 10 eukaryote families, defined as Classes A-J. These receptors are classified according to their sequences, although in each class they are further classified based in the variations of the sequence. Their ability to bind a range of ligands is reflected on the biological functions such as clearance of modified lipoproteins and pathogens. SR members regulate pathophysiological states including atherosclerosis, pathogen infections, immune surveillance, and cancer. Here, we review our current understanding of SR structure and function implicated in health and disease.

【 授权许可】

Unknown