Walking down Skeletal Muscle Lane: From Inflammasome to Disease

Cells

Nicolas Dubuisson¹  María A. Davis-López de Carrizosa¹  Sonia M. Brichard¹  Michel Abou-Samra¹  Romain Versele¹  Camille M. Selvais¹ 

[1] Endocrinology, Diabetes and Nutrition Unit, Institute of Experimental and Clinical Research, Medical Sector, Université Catholique de Louvain, 1200 Brussels, Belgium;

关键词: skeletal muscle;    NLRP3;    inflammasome;    pyroptosis;    metabolic syndrome;    sepsis;   

DOI  :  10.3390/cells10113023

来源: DOAJ

【 摘 要 】

Over the last decade, innate immune system receptors and sensors called inflammasomes have been identified to play key pathological roles in the development and progression of numerous diseases. Among them, the nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin domain-containing protein 3 (NLRP3) inflammasome is probably the best characterized. To date, NLRP3 has been extensively studied in the heart, where its effects and actions have been broadly documented in numerous cardiovascular diseases. However, little is still known about NLRP3 implications in muscle disorders affecting non-cardiac muscles. In this review, we summarize and present the current knowledge regarding the function of NLRP3 in diseased skeletal muscle, and discuss the potential therapeutic options targeting the NLRP3 inflammasome in muscle disorders.

【 授权许可】

Unknown