Dexmedetomidine alleviates hepatic ischaemia‐reperfusion injury via the PI3K/AKT/Nrf2‐NLRP3 pathway

Journal of Cellular and Molecular Medicine

Yiqiao Wang¹  Yuanhai Li²  Hainie Zhang²  Gaolin Qiu²  Yan Wu³  Gao Cheng⁴  Leilei Zhu⁴  Weiwei Wu⁴ 

[1] Department of Anesthesiology, Anhui NO.2 Provincial People's Hospital, Hefei, China;Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;Department of Anesthesiology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China;Department of Anesthesiology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China;

关键词: Dexmedetomidine;    hepatic ischaemia‐reperfusion injury;    hypoxia/reoxygenation cell model;    JUND;    miR‐494;    NLRP3;    PI3K/AKT/Nrf2 pathway;    pyroptosis;   

DOI  :  10.1111/jcmm.16871

来源: Wiley

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