Are Multiple Chemosensory Systems Accountable for COVID-19 Outcome?

Journal of Clinical Medicine

Antonio Caretta¹  Carla Mucignat-Caretta² 

[1] Department of Food and Drug Science, University of Parma, 43100 Parma, Italy;NIBB—National Institute for Biostructures and Biosystems, 00136 Rome, Italy;

关键词: SARS-CoV-2;    COVID-19;    olfaction;    taste;    carotid body;    oxygen sensing;   

DOI  :  10.3390/jcm10235601

来源: DOAJ

【 摘 要 】

Chemosensory systems (olfaction, taste, trigeminus nerve, solitary chemoreceptor cells, neuroendocrine pulmonary cells, and carotid body, etc.) detect molecules outside or inside our body and may share common molecular markers. In addition to the impairment of taste and olfaction, the detection of the internal chemical environment may also be incapacitated by COVID-19. If this is the case, different consequences can be expected. (1) In some patients, hypoxia does not trigger distressing dyspnea (“silent” hypoxia): Long-term follow-up may determine whether silent hypoxia is related to malfunctioning of carotid body chemoreceptors. Moreover, taste/olfaction and oxygen chemoreceptors may be hit simultaneously: Testing olfaction, taste, and oxygen chemoreceptor functions in the early stages of COVID-19 allows one to unravel their connections and trace the recovery path. (2) Solitary chemosensory cells are also involved in the regulation of the innate mucosal immune response: If these cells are affected in some COVID-19 patients, the mucosal innate immune response would be dysregulated, opening one up to massive infection, thus explaining why COVID-19 has lethal consequences in some patients. Similar to taste and olfaction, oxygen chemosensory function can be easily tested with a non-invasive procedure in humans, while functional tests for solitary chemosensory or pulmonary neuroendocrine cells are not available, and autoptic investigation is required to ascertain their involvement.

【 授权许可】

Unknown