An efficient synthesis of furan-3(2H)-imine scaffold from alkynones

Royal Society Open Science

Raed A. AlQawasmeh¹  Ihsan A. Shehadi¹  Eyad A. Younes²  Da'san M. M. Jaradat³  Anas J. Rasras³ 

[1] College of Science, Department of Chemistry, University of Sharjah, Pure and Applied Chemistry Research Group, PO Box 27272, Sharjah, United Arab Emirates;Department of Chemistry, Faculty of Science, The Hashemite University, PO Box 330127, Zarqa 13133, Jordan;Faculty of Science, Department of Chemistry, Al-Balqa Applied University, PO Box 19117, Al-Salt, Jordan;

关键词: efficient;    synthesis;    furan-3(2H)-imine;    scaffold;    alkynones;    authors;   

DOI  :  10.1098/rsos.211145

来源: DOAJ

【 摘 要 】

A novel efficient method to generate spiro furan-3(2H)-imine derivatives is established by the reaction between the α,β-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2H)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).

【 授权许可】

Unknown