An Efficient and Chemoselective Procedure for Acylal Synthesis

Molecules

Da-He Fan¹  Hui Wang¹  Xing-Xing Mao¹ 

[1] ¹School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224003, China ²Department of Chemistry, Shaoxing University, Shaoxing 312000, China

关键词: efficient;    novel catalyst;    heterogeneous;    green process;   

DOI  :  10.3390/molecules15096493

来源: mdpi

【 摘 要 】

A novel heterogeneous efficient procedure has been developed for the chemoselective synthesis of acylals (1,1-diacetates) under solvent-free conditions. A novel catalyst prepared by the sulfuric acid catalyzed copolymerization of p-toluenesulfonic acid and paraformaldehyde displays extremely high activities for the title reactions, affording average yields over 90% within several minutes. A comparative study showed that the novel catalyst has much higher activity than other catalysts used for this purpose. Besides, the novel catalyst displays chemoselectivity for the protection of aldehydes in the presence of ketones. In addition the high acidity (4.0 mmol/g), thermal stability (200 ºC) and easy reusability make the novel catalyst one of the best choices for the process.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.