Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up

BMC Endocrine Disorders

Jonathan Mathias Baier¹  Esben Laugesen¹  Kristian Løkke Funck¹  Liv Vernstrøm¹  Per Løgstrup Poulsen¹ 

[1] Department of Internal Medicine and Endocrinology and Steno Diabetes Center Aarhus, Aarhus University Hospital;

关键词: Endothelial dysfunction;    Endothelial function;    Type 2 diabetes;    Physical activity;    Reactive hyperemia index;    Peripheral arterial tonometry;   

DOI  :  10.1186/s12902-021-00857-9

来源: DOAJ

【 摘 要 】

Abstract Background The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up. Methods We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI). Results Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28). Conclusions Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls.

【 授权许可】

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