Botulinum Toxin: An Update on Pharmacology and Newer Products in Development

Toxins

Suparna Chatterjee¹  Supriyo Choudhury¹  Hrishikesh Kumar¹  MarkR. Baker² 

[1] Department of Neurology, Institute of Neurosciences Kolkata, Kolkata 700017, India;Departments of Neurology and Clinical Neurophysiology, Royal Victoria Infirmary, Queen Victoria Rd, Newcastle upon Tyne NE1 4LP, UK;

关键词: botulinum toxin;    dystonia;    recombinant botulinum toxin;    acetylcholine;    neuromuscular blockade;   

DOI  :  10.3390/toxins13010058

来源: DOAJ

【 摘 要 】

Since its introduction as a treatment for strabismus, botulinum toxin (BoNT) has had a phenomenal journey and is now recommended as first-line treatment for focal dystonia, despite short-term clinical benefits and the risks of adverse effects. To cater for the high demand across various medical specialties, at least six US Food and Drug Administration (FDA)-approved formulations of BoNT are currently available for diverse labelled indications. The toxo-pharmacological properties of these formulations are not uniform and thus should not be used interchangeably. Synthetic BoNTs and BoNTs from non-clostridial sources are not far from clinical use. Moreover, the study of mutations in naturally occurring toxins has led to modulation in the toxo-pharmacokinetic properties of BoNTs, including the duration and potency. We present an overview of the toxo-pharmacology of conventional and novel BoNT preparations, including those awaiting imminent translation from the laboratory to the clinic.

【 授权许可】

Unknown