Extracellular Vesicles as Biomarkers and Therapeutic Tools: From Pre-Clinical to Clinical Applications

Biology

MariaChiara Ciferri¹  Rodolfo Quarto¹  Roberta Tasso¹ 

[1] Department of Experimental Medicine, University of Genova, 16132 Genova, Italy;

关键词: extracellular vesicles;    exosomes;    cancer;    biomarkers;    liquid biopsy;    therapy;   

DOI  :  10.3390/biology10050359

来源: DOAJ

【 摘 要 】

Extracellular vesicles (EVs) are ubiquitous masters of intercellular communication, being detectable in tissues, circulation, and body fluids. Their complex cargo reflects the (patho)physiologic status of the cells from which they originate. Due to these properties, the potential of EVs, and in particular exosomes, to serve as biomarkers or therapeutics has grown exponentially over the past decade. On one side, numerous studies have demonstrated that EV-associated nucleic acids and proteins are implicated in cancer progression, as well as neurodegenerative, infectious, and autoimmune disorders. On the other, the therapeutic use of EVs secreted by various cell types, and in particular stem/progenitor cells, present significant advantages in comparison to the corresponding parental cells, such as the less complex production and storage conditions. In this review, we examine some of the major pre-clinical studies dealing with EVs and exosomes, that led to the development of numerous completed clinical trials.

【 授权许可】

Unknown