Biomimetic hydroxyapatite/poly xylitol sebacic adibate/vitamin K nanocomposite for enhancing bone regeneration

Artificial Cells, Nanomedicine, and Biotechnology

Sumathra Murugan¹  Seoh Wei Teh²  Haiyan Pan³  Zhipeng Dai⁴  Minyan Dang⁵  Wenzhi Zhang⁵ 

[1] Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India;Department of Biomedical Science, University Putra Malaysia (UPM), Serdang, Malaysia;Department of Orthopaedics, Ankang Hospital of Traditional Chinese Medicine, Ankang, Shaanxi Province, China;Department of Orthopedics, Henan Provincial People’s Hospital, Zhengzhou City, Henan Province, China;Innoscience Research SdnBhd, Subang Jaya, Selangor, Malaysia;

关键词: Biomimetic;    bone regeneration;    hydroxyapatite;    polymer;    vitamin K;   

DOI  :  10.1080/21691401.2019.1573183

来源: DOAJ

【 摘 要 】

Hydroxyapatite (HAP) is a significant bone mineral that establishes bone strength. HAP composites in combination with biodegradable and bioactive polymer poly xylitol sebacic adipate (PXSA) would result in a constant release at target sites. Numerous studies have shown that vitamin K (VK) might possess a vital function in bone metabolism. The purpose of the present study was to inspect the synthesized composite HAP/PXSA/VK in developing polymeric biomaterials composite for the application of bone tissue regeneration. FTIR, X-ray diffraction, SEM and TEM techniques were applied to characterize the prepared composites. The release of VK from the HAP/PXSA/VK composite was evidenced through UV–Vis spectroscopy. In vitro studies proved that the HAP/PXSA/VK composite is appropriate for mesenchymal stem cell culture. Compared to pure HAP prepared following the same method, HAP/PXSA/VK composite provided favourable microstructures and good biodegradation distinctiveness for the application of tissue engineering, as well as tissue in-growth characteristics and improved scaffold cell penetration. This work reveals that the HAP/PXSA/VK composites have the potential for applications in bone tissue engineering.

【 授权许可】

Unknown