THE ASSESSMENT OF BIOMARKER COMPLEX IN MEN WITH CORONARY ATHEROSCLEROSIS

Российский кардиологический журнал

I. S. Murashov¹  O. V. Kamenskaya¹  A. M. Chernjavsky¹  A. V. Kurguzov¹  Yu. I. Ragino²  E. M. Stakhneva²  E. V. Kashtanova²  Ya. V. Polonskaya² 

[1] E.N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology;SRI of Therapy and Prevention Medicine of Siberian Division of RAS;

关键词: atherosclerosis;    biomarkers;    lipids;    antioxidants;    oxidation;   

DOI  :  10.15829/1560-4071-2016-2-60-64

来源: DOAJ

【 摘 要 】

Aim. To study relation of antioxidant status, lipid and carbohydrate metabolism and to evaluate the influence of these factors on coronary atherosclerotic lesions vulnerability.Material and methods. Totally, 104 men included — mean age 60,74±8,1 y., selected to control (non-CHD) and main group with angiographically verified coronary atherosclerosis and CHD. Main group was divided to 2 subgroups. The first included 38 men, who had unstable plaques, the second — 34 men who had been diagnosed only stable plaques in coronary arteries. In all serum specimens we measured: malonic dialdehyde concentration (MD); oxidation resistance of low density lipoproteides (LDL), general level of oxidation stress; level of retinol, β-carotene in LDL; total cholesterol; high density cholesterol (HDL); cholesterol of low density lipoproteides (CLDL); triglycerides (TG); glucose; C-peptide and insulin. Statistics was done on the SPSS software (13.0).Results. In men with coronary atherosclerosis, comparing to the control group, among the studied complex of lipid-lipoproteide, carbohydrate and oxidation-antioxidant biomarkers in blood there were elevated CLDL, TG, ApoB, relation ApoB/ApoA, LP(a), C-peptide, grade of oxidation stress and CHDL level decreased, as retinol, β-carotene and LDL resistance to oxidation. Existence of unstable atherosclerotic lesions in vessel wall determined interrelation of CHDL with TG (p<0,01) and resistance of LDL to oxidation (p<0,05). Also, as in the second subgroup the level of CHDL correlated with CLDL (p<0,01), β-carotene and retinol (p<0,05). While studying the relation of lipid and carbohydrate metabolisms there was relation of glucose level with those parameters as CHDL, CLDL, TG (p<0,01), apo B, LP(a), ApoB/ApoA (p<0,05).Conclusion. The data obtained in the study points on the relation of parameters of lipid, carbohydrate and oxidation-antioxidant status with coronary atherosclerosis development and possibility of atherosclerotic lesion instability.

【 授权许可】

Unknown