Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies

Frontiers in Immunology

Véronique Maguer-Satta¹  Nathalie M. Mazure²  Jean-François Peyron²  Fatima Mechta-Grigoriou³  Valérie Trichet⁴  Olivier Herault⁶  Stéphane J.C. Mancini⁷  Isabelle Corre⁸  Gwendal Lazennec^1,10  Marie-Caroline Le Bousse-Kerdilès^1,12  Fawzia Louache^1,12  Julie Gavard^1,13  Karl Balabanian^1,15 

[1] 0Cancer Research Center of Lyon (CRCL), CNRS UMR5286, INSERM U1052, Lyon 1 university, Lean Bérard Center, Lyon, France;1INSERM U1065, C3M, University of Côte d’Azur (UCA), Nice, France;2Stress and Cancer Laboratory, Institut Curie, INSERM U830, Paris Sciences et Lettres (PSL) Research University, Team Babelized Ligue Nationale Contre le Cancer (LNCC), Paris, France;3INSERM UMR1238 Phy-Os, Université de Nantes, Nantes, France;4Centre National de la Recherche scientifique (CNRS) ERL7001 LNOx, EA7501, Tours University, Tours, France;5Department of Biological Hematology, Tours University Hospital, Tours, France;Cancéropole Grand-Ouest, NET network “Niches and Epigenetics of Tumors”, Nantes, France;Center for Research in Cancerology and Immunology Nantes-Angers (CRCINA), Signaling in Oncogenesis Angiogenesis and Permeability (SOAP), INSERM UMR1232, Centre National de la Recherche scientifique (CNRS) ERL600, Université de Nantes, Nantes, France;Centre National de la Recherche scientifique (CNRS) GDR3697, Micronit “Microenvironment of Tumor Niches”, Tours, France;Centre National de la Recherche scientifique (CNRS) UMR9005, SYS2DIAG-ALCEDIAG, Montpellier, France;INSERM UMR1236, Rennes 1 University, Etablissement Français du Sang Bretagne, Rennes, France;INSERM UMRS-MD1197, Paris-Saclay University, Paul-Brousse Hospital, Villejuif, France;Integrated Center for Oncology, St. Herblain, France;Saint-Louis Research Institute, University of Paris, EMiLy, INSERM U1160, Paris, France;The Organization for Partnerships in Leukemia (OPALE) Carnot Institute, The Organization for Partnerships in Leukemia, Paris, France;

关键词: microenvironment;    cancer-associated fibroblasts (CAFs);    mesenchymal stem/stromal cells (MSCs);    cytokines and chemokines;    energy/oxidative metabolism;    mitochondrial transfer;   

DOI  :  10.3389/fimmu.2021.766275

来源: DOAJ

【 摘 要 】

Knowledge about the hematopoietic niche has evolved considerably in recent years, in particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity in the human bone marrow, in particular in a context of hematological malignancy, is more difficult to decipher by these strategies and could benefit from the knowledge acquired on the niches of solid tumors. Indeed, some common features can be suspected, since the bone marrow is a frequent site of solid tumor metastases. Recent research on solid tumors has provided very interesting information on the interactions between tumoral cells and their microenvironment, composed notably of mesenchymal, endothelial and immune cells. This review thus focuses on recent discoveries on tumor niches that could help in understanding hematopoietic niches, with special attention to 4 particular points: i) the heterogeneity of carcinoma/cancer-associated fibroblasts (CAFs) and mesenchymal stem/stromal cells (MSCs), ii) niche cytokines and chemokines, iii) the energy/oxidative metabolism and communication, especially mitochondrial transfer, and iv) the vascular niche through angiogenesis and endothelial plasticity. This review highlights actors and/or pathways of the microenvironment broadly involved in cancer processes. This opens avenues for innovative therapeutic opportunities targeting not only cancer stem cells but also their regulatory tumor niche(s), in order to improve current antitumor therapies.

【 授权许可】

Unknown