Serum lipophilic antioxidants levels are associated with leucocyte telomere length among US adults

Lipids in Health and Disease

Mohsen Mazidi¹  L. J. Cheskin²  Maciej Banach³  Andre Pascal Kengne⁴ 

[1] Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology;Department of Health, Johns Hopkins Weight Management Center Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University;Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz;Non-Communicable Disease Research Unit, South African Medical Research Council and University of Cape Town;

关键词: Telomere length;    Antioxidant;    National health and nutrition examination survey;   

DOI  :  10.1186/s12944-018-0781-x

来源: DOAJ

【 摘 要 】

Abstract Background To examine the association between serum concentrations of antioxidant and telomere length (TL) in U.S adults. Methods Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on TL measures from 2001 to 2002 were included. Serum lipophilic antioxidants level was measured using high performance liquid chromatography with photodiode array detection. We used analysis of co-variance and multivariable-adjusted linear regression models, accounting for the survey design and sample weights. Results Of the 5992 eligible participants, 47.5% (n = 2844) were men. The mean age was 46.9 years overall, 47.2 years in men and 46.6 in women (p = 0.071). In age, sex, race, education, marital status, adiposity, smoking, C-reactive protein adjusted linear regressions, antioxidant, serum α-carotene, trans-β-carotene, cis- β-carotene, β-cryptoxanthin and combined Lutein/zeaxanthin were positively and significantly associated with TL (all p < 0.001). Conclusions Our findings support a possible positive association between serum concentrations of lipophylic antioxidant and TL. The implications of this association deserve further investigation.

【 授权许可】

Unknown