Polyfluoroalkyl chemicals and the risk of kidney stones in US adults: A population-based study

Ecotoxicology and Environmental Safety

Qiang Hu¹  Bin Xu²  Saisai Chen³  Ming Luo³  Yu Chen³  Ming Chen³  Jianping Wu⁴  Weipu Mao⁴  Jiang Geng⁵  Ziwei Zhang⁵ 

[1] Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China;Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China;Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China;Department of Urology, People’s Hospital of Putuo District, Shanghai 200060, China;Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China;

关键词: Kidney stone;    Polyfluoroalkyl chemicals;    Perfluorohexane sulfonic acid;    National health and nutrition examination survey;    Cross-sectional survey;   

DOI  :  

来源: DOAJ

【 摘 要 】

The potential nephrotoxicity of polyfluoroalkyl chemicals (PFCs) have received extensive attention. However, the relationship between PFCs and the risk of kidney stones remain unclear. This study aimed to examine the level of PFCs in the US population and its relationship with the risk of kidney stones. We investigated the serum levels of six PFCs in 8453 adult participants (≥20 years) from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016, including perfluorodecanoic acid (PFDE), perfluorohexane sulfonic acid (PFHS), 2-(N-methyl-perfluorooctane sulfonamido) acetate (MPAH), perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUA), and perfluorododecanoic acid (PFDO). Logistic regression model was used to evaluate the correlation between PFCs and kidney stones. Of the 8453 participants, 787 self-reported a history of kidney stones. After adjusting for gender, age, race, education, marital status, body mass index (BMI), hypertension, diabetes and estimated glomerular filtration rate (eGFR), we found that total PFCs and PFHS were positively correlated with the risk of kidney stones. Compared with the lowest tertile, the odds ratios with 95% confidence intervals (CI) with increasing tertiles were 1.30 (95% CI,1.08–1.59, p = 0.007) and 1.25 (95 CI%,1.00–1.52, p = 0.024) for total PFCs and 1.24 (95 CI%,1.03–1.51, p = 0.032), and 1.35 (95 CI,1.10–1.68, p = 0.005) for PFHS. Our study shows that total PFCs and PFHS were associated with an increased risk of kidney stones.

【 授权许可】

Unknown