The Tumor–Fat Interface Volume of Breast Cancer on Pretreatment MRI Is Associated with a Pathologic Response to Neoadjuvant Chemotherapy

Biology

Hyunjin Park¹  Hwan-ho Cho²  Kyounglan Ko³  EunSook Ko⁴  Minsu Park⁵  SungHoon Sim⁶  Young-Hyuck Im⁷  NaYoung Hwang⁸ 

[1] Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Korea;Department of Electronic, Electrical and Computer Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Korea;Department of Radiology & Cancer Research Institute, National Cancer Center, Goyang-si 10408, Korea;Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea;Department of Statistics, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea;Division of Hematology/Oncology, Department of Medicine, National Cancer Center, Goyang-si 10408, Korea;Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea;Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Korea;

关键词: breast cancer;    neoadjuvant chemotherapy;    MRI;    adipose tissue;    pathological complete response;   

DOI  :  10.3390/biology9110391

来源: DOAJ

【 摘 要 】

Adipocytes are active sources of numerous adipokines that work in both a paracrine and endocrine manner. It is not known that the direct contact between tumor and neighboring fat measured by pretreatment breast magnetic resonance imaging (MRI) affects treatment outcomes to neoadjuvant chemotherapy (NAC) in breast cancer patients. A biomarker quantifying the tumor–fat interface volume from pretreatment MRI was proposed and used to predict pathologic complete response (pCR) in breast cancer patients treated with NAC. The tumor–fat interface volume was computed with data-driven clustering using multiphasic MRI. Our approach was developed and validated in two cohorts consisting of 1140 patients. A high tumor–fat interface volume was significantly associated with a non-pCR in both the development and validation cohorts (p = 0.030 and p = 0.037, respectively). Quantitative measurement of the tumor–fat interface volume based on pretreatment MRI may be useful for precision medicine and subsequently influence the treatment strategy of patients.

【 授权许可】

Unknown