AnaBioPlus: a new package for parameter estimation and simulation of bioprocesses

Brazilian Journal of Chemical Engineering

关键词: Free software, bioprocess;    kinetic modeling;    parameter estimation;    simulation;   

DOI  :  10.1590/0104-6632.20170344s20150673

来源: DOAJ

【 摘 要 】

Abstract A very important step in the study of bioprocesses is the modeling and simulation of bioreactors. This paper presents the AnaBioPlus software package, which was developed for teaching and research purposes concerning the analysis of bioreactors. The package consists of two programs: OptimusFerm and SimulaFerm. OptimusFerm allows the analysis of experimental batch cultivation data sets in order to estimate parameters of kinetic models by means of a differential evolution method. SimulaFerm performs simulations obtaining values of cell growth, product formation, and limiting substrate consumption for batch, fed-batch and continuous cultivations. Thirty-two kinetic models of cell growth are available in OptimusFerm and SimulaFerm. Two case studies are described in order to illustrate the use of AnaBioPlus. The results show that AnaBioPlus is a very useful tool for the analysis of bioprocesses. Furthermore, it presents a user-friendly graphical interface and is freely available to users, in both English and Portuguese versions.

【 授权许可】

Unknown