The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Advanced Science

Wenwen Xu¹  Jianqiao Zhou¹  Caihong Dong²  Wei Feng³  Yu Chen³  Luodan Yu³  Huiijng Xiang⁴ 

[1] Department of Ultrasound Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 P. R. China;Department of Ultrasound Zhongshan Hospital Fudan University Shanghai 200032 P. R. China;School of Life Sciences Shanghai University Shanghai 200444 P. R. China;State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China;

关键词: antibacteria;    bioimaging;    cancer therapy;    copper nanoparticles;    nanomedicine;    tissue regeneration;   

DOI  :  10.1002/advs.202001549

来源: DOAJ

【 摘 要 】

Abstract As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu‐involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu‐composed nanoparticles. Based on the very‐recent significant progresses of Cu‐involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu‐composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu‐based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the “Copper Age,” these Cu‐involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.

【 授权许可】

Unknown