Prospective surveillance for invasive Staphylococcus aureus and group A Streptococcus infections in a setting with high community burden of scabies and impetigo

International Journal of Infectious Diseases

Daniel Engelman¹  Jyotishna Mani²  Adam Jenney²  Jessica Paka³  Lucia Romani⁴  Sera Taole⁵  Tuliana Cua⁵  Margot Whitfeld⁶  Andrew C. Steer⁶  Natalie Carvalho⁶  John Kaldor⁶  Joseph Kado⁶  Handan Wand⁷  Vika Soqo⁷  Mike Kama⁷  Meciusela Tuicakau⁷  Li Jun Thean⁷  Aalisha Sahukhan⁷ 

[1] Corresponding author at: Murdoch Children’s Research Institute, Royal Children’s Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.;Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia;Melbourne Children’s Global Health, Melbourne Children’s Campus, The Royal Children’s Hospital, Parkville, Victoria, Australia;College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji;Kirby Institute, University of New South Wales, Kensington, New South Wales, Australia;Ministry of Health and Medical Services, Suva, Fiji;Tropical Diseases Group, Murdoch Children’s Research Institute, Parkville, Victoria, Australia;

关键词: Invasive infections;    Staphylococcus aureus;    Group A Streptococcus;    Streptococcus pyogenes;    Skin and soft tissue infection;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Invasive Staphylococcus aureus (iSA) and group A Streptococcus (iGAS) impose significant health burdens globally. Both bacteria commonly cause skin and soft tissue infections (SSTIs), which can result in invasive disease. Understanding of the incidence of iSA and iGAS remains limited in settings with a high SSTI burden. Methods: Prospective surveillance for admissions with iSA or iGAS was conducted at the referral hospital in Fiji’s Northern Division over 48 weeks between July 2018 and June 2019. Results: There were 55 admissions for iSA and 15 admissions for iGAS (incidence 45.2 and 12.3 per 100,000 person-years, respectively). The highest incidence was found in patients aged ≥65 years (59.6 per 100,000 person-years for iSA and iGAS). The incidence of iSA was higher in indigenous Fijians (iTaukei) (71.1 per 100,000 person-years) compared with other ethnicities (incidence rate ratio 9.7, 95% confidence interval 3.5–36.9). SSTIs were found in the majority of cases of iSA (75%) and iGAS (53.3%). Thirteen of the 14 iGAS strains isolated belonged to emm cluster D (n = 5) or E (n = 8). The case fatality rate was high for both iSA (10.9%) and iGAS (33.3%). Conclusions: The incidence of iSA and iGAS in Fiji is very high. SSTIs are common clinical foci for both iSA and iGAS. Both iSA and iGAS carry a substantial risk of death. Improved control strategies are needed to reduce the burden of iSA and iGAS in Fiji.

【 授权许可】

Unknown