Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions

Frontiers in Physiology

Brian C. Toner¹  Basel White¹  Kendra A. Batchelder¹  Andre Khalil²  Genrietta Freynd³  Igor Antipev³  Alain Arneodo⁴  Evgeniya Gerasimova-Chechkina⁵ 

[1] CompuMAINE Laboratory, University of Maine, Orono, ME, United States;Department of Chemical and Biomedical Engineering, University of Maine, Orono, ME, United States;Department of Pathology, Perm State Medical University Named After Academician E. A. Wagner, Perm, Russia;Laboratoire Ondes et Matière d’Aquitaine, Universite de Bordeaux, Bordeaux, France;Laboratory of Physical Foundations of Strength, Institute of Continuous Media Mechanics UB RAS, Perm, Russia;

关键词: Radiomics;    tissue homeostasis;    mammography;    wavelets;    breast density;    fractals;   

DOI  :  10.3389/fphys.2021.660883

来源: DOAJ

【 摘 要 】

The 2D wavelet transform modulus maxima (WTMM) method is used to perform a comparison of the spatial fluctuations of mammographic breast tissue from patients with invasive lobular carcinoma, those with invasive ductal carcinoma, and those with benign lesions. We follow a procedure developed and validated in a previous study, in which a sliding window protocol is used to analyze thousands of small subregions in a given mammogram. These subregions are categorized according to their Hurst exponent values (H): fatty tissue (H ≤ 0.45), dense tissue (H ≥ 0.55), and disrupted tissue potentially linked with tumor-associated loss of homeostasis (0.45 < H < 0.55). Following this categorization scheme, we compare the mammographic tissue composition of the breasts. First, we show that cancerous breasts are significantly different than breasts with a benign lesion (p-value ∼ 0.002). Second, the asymmetry between a patient’s cancerous breast and its contralateral counterpart, when compared to the asymmetry from patients with benign lesions, is also statistically significant (p-value ∼ 0.006). And finally, we show that lobular and ductal cancerous breasts show similar levels of disruption and similar levels of asymmetry. This study demonstrates reproducibility of the WTMM sliding-window approach to help detect and characterize tumor-associated breast tissue disruption from standard mammography. It also shows promise to help with the detection lobular lesions that typically go undetected via standard screening mammography at a much higher rate than ductal lesions. Here both types are assessed similarly.

【 授权许可】

Unknown