Association between PTPN22/CTLA-4 Gene Polymorphism andAllergic Rhinitis with Asthma in Children

Iranian Journal of Allergy, Asthma and Immunology

Xiao Qiang Wang¹  Shang Hua Song¹  Su Ling Hong¹  Xia Ke¹  Yang Shen¹ 

[1] Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China;

关键词: Allergic rhinitis;    Asthma;    Pediatrics;    Genetic polymorphism;    Cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4);    Single nucleotide polymorphism (SNP);   

DOI  :  

来源: DOAJ

【 摘 要 】

Allergic rhinitis (AR) is an IgE-mediated upper airway disease, and its impact on asthma has been widely recognized. Protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and the cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) gene polymorphisms have been reported to be associated with several immune-related diseases. Here we investigated the reffect of these two genes’ polymorphisms on the risk of AR and asthma in Chinese Han children. A total of 106 AR patients, 112 AR with asthma patients, and 109 healthy children were enrolled in the study. The SNPs of PTPN22 (rs2488457, rs1310182, rs3789604) and CTLA-4 (rs3087243, rs11571302, rs11571315, rs231725, rs335219727, and rs4553808) were genotyped using a PCR-restriction fragment length polymorphism assay. For PTPN22, an increased prevalence of the CC genotype and C allele in rs1310182 were identified in AR group. For CTLA-4, AA genotype and A allele in rs3087243 and rs231725 were increased in AR with asthma group while in AR group, AA genotype and A allele in rs231725 were obviously decreased. This study reveals a significant association between SNPs in PTPN22, CTLA-4 gene and AR with asthma in Chinese Han children, which might be susceptibility factors for AR and asthma.

【 授权许可】

Unknown