Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study

Frontiers in Human Neuroscience

Linqi Dai¹  Xiao Li¹  Li Kuang¹  Qian Huang¹  Yi Zhou¹  Ming Ai¹  Renqiang Yu²  Xiaoyue Qin³  Xiaolu Chen⁴ 

[1] Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;Department of the First Clinical Medicine, Chongqing Medical University, Chongqing, China;The First Branch, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;

关键词: MDD;    adolescent;    ALFF;    degree centrality;    resting-state fMRI;    suicidal ideation;   

DOI  :  10.3389/fnhum.2021.762343

来源: DOAJ

【 摘 要 】

Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) is strongly predictive of death by suicide, and electroconvulsive therapy (ECT) is effective for MDD, especially in patients with SI. In the present study, we aimed to determine differences in resting-state functional magnetic resonance imaging (rs-fMRI) in 14 adolescents aged 12–17 with MDD and SI at baseline and after ECT. All participants were administered the Hamilton Depression Scale (HAMD) and Beck Scale for Suicide Ideation (BSSI) and received rs-fMRI scans at baseline and after ECT. Following ECT, the amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) significantly decreased in the right precentral gyrus, and the degree centrality (DC) decreased in the left triangular part of the inferior frontal gyrus and increased in the left hippocampus. There were significant negative correlations between the change of HAMD (ΔHAMD) and ALFF in the right precentral gyrus at baseline, and between the change of BSSI and the change of fALFF in the right precentral gyrus. The ΔHAMD was positively correlated with the DC value of the left hippocampus at baseline. We suggest that these brain regions may be indicators of response to ECT in adolescents with MDD and SI.

【 授权许可】

Unknown