Distinct Changes in Global Brain Synchronization in Early-Onset vs. Late-Onset Parkinson Disease

Frontiers in Aging Neuroscience

Yijuan Xiang¹  Sainan Cai²  Zhenni Mao²  Lin Zhang²  Min Wang²  Changlian Tan²  Tianyu Wang²  Haiyan Liao²  Junli Li²  Qin Shen²  Yuheng Zi² 

[1] Department of Radiology, Hunan Province Maternal and Child Health Care Hospital, Changsha, China;Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China;

关键词: early-onset Parkinson disease;    late-onset Parkinson disease;    global brain synchronization;    degree centrality;    resting-state functional MRI (R-fMRI);   

DOI  :  10.3389/fnagi.2020.604995

来源: DOAJ

【 摘 要 】

Early- and late-onset Parkinson’s disease (EOPD and LOPD, respectively) have different risk factors, clinical features, and disease course; however, the functional outcome of these differences have not been well characterized. This study investigated differences in global brain synchronization changes and their clinical significance in EOPD and LOPD patients. Patients with idiopathic PD including 25 EOPD and 24 LOPD patients, and age- and sex-matched healthy control (HC) subjects including 27 younger and 26 older controls (YCs and OCs, respectively) were enrolled. Voxel-based degree centrality (DC) was calculated as a measure of global synchronization and compared between PD patients and HC groups matched in terms of disease onset and severity. DC was decreased in bilateral Rolandic operculum and left insula and increased in the left superior frontal gyrus (SFG) and precuneus of EOPD patients compared to YCs. DC was decreased in the right putamen, mid-cingulate cortex, bilateral Rolandic operculum, and left insula and increased in the right cerebellum-crus1 of LOPD patients compared to OCs. Correlation analyses showed that DC in the right cerebellum-crus1 was inversely associated with the Hamilton Depression Scale (HDS) score in LOPD patients. Thus, EOPD and LOPD patients show distinct alterations in global synchronization relative to HCs. Furthermore, our results suggest that the left SFG and right cerebellum-crus1 play important roles in the compensation for corticostriatal–thalamocortical loop injury in EOPD and LOPD patients, whereas the cerebellum is a key hub in the neural mechanisms underlying LOPD with depression. These findings provide new insight into the clinical heterogeneity of the two PD subtypes.

【 授权许可】

Unknown