Influences of Resveratrol on the Proliferation of Cholangiocarcinoma Cells and Expression of p21 and p27 Proteins

Journal of International Translational Medicine

Huaxiang Qian¹  Ma Zhuo²  Yong Liu²  Jianzhong Xu² 

[1] Department of Internal Medicine, Changzhou Tumor Hospital Affiliated to Soochow University, Changzhou, Jiangsu, 213001, China.;Medical Oncology Department, Changzhou Tumor Hospital Affiliated to Soochow University, Changzhou, Jiangsu, 213001, China;

关键词: Resveratrol;    Cholangiocarcinoma;    Proliferation;    p21;    p27;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: To explore the effects of resveratrol on the proliferation of cholangiocarcinoma cells and expression of p21 and p27 proteins. Methods: The influences of resveratrol on the proliferation of cholangiocarcinoma cells and expression of p21 and p27 proteins were detected by methyl thiazolyl tetrazolium (MTT) method and Western blotting method, respectively. Results: Resveratrol had a conspicuous inhibitory effect on the proliferation of cholangiocarcinoma QBC939 cells, and was concentration- and time-dependant (P < 0.05). In addition, it could up regulate the expression of p21 and p27 proteins obviously, and was concentration-dependant (P <0.05). Conclusion: Resveratrol can significantly inhibit the proliferation of cholangiocarcinoma QBC939 cells, which may be related to regulation of p21 and p27 expression and negative regulation to cell cycles.

【 授权许可】

Unknown