Locked and Unlocked Nucleosides in Functional Nucleic Acids

Molecules

关键词: locked nucleic acid (LNA);    unlocked nucleic acid (UNA);    aptamer;    ribozyme;    deoxyribozymes (DNAzyme);   

DOI  :  10.3390/molecules16064511

来源: DOAJ

【 摘 要 】

Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.

【 授权许可】

Unknown