Locked and Unlocked Nucleosides in Functional Nucleic Acids

Molecules

Holger Doessing¹ 

[1] Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M 5230, Denmark

关键词: locked nucleic acid (LNA);    unlocked nucleic acid (UNA);    aptamer;    ribozyme;    deoxyribozymes (DNAzyme);   

DOI  :  10.3390/molecules16064511

来源: mdpi

【 摘 要 】

Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.