Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance

Frontiers in Endocrinology

Takaaki eKayano¹  Toru eHosoi¹  Koichiro eOzawa¹  Shota eYokoyama¹  Tsuyoshi eMiyahara¹ 

[1] Hiroshima University;

关键词: Depression;    Endoplasmic Reticulum Stress;    Fluvoxamine;    Leptin;    Obesity;    stat3;   

DOI  :  10.3389/fendo.2012.00012

来源: DOAJ

【 摘 要 】

Increasing evidence indicates that endoplasmic reticulum stress (ER stress) is involved in the development of metabolic syndrome.However, pharmacological treatments targeting ER stress are not well understood.In the present study, we found that fluvoxamine, a selective serotonin reuptake inhibitor used for depression, can attenuate ER stress-induced leptin resistance, i.e. insensitivity to the anti-obesity hormone leptin.Treatment with tunicamycin, an ER stress-inducing reagent, caused cell death which was significantly inhibited by fluvoxamine.Leptin activates JAK2-STAT3 signaling.ER stress caused an impairment of leptin-induced STAT3 phosphorylation which was reversed by fluvoxamine.Fluvoxamine would be a novel leptin-sensitizing drug, which targets ER stress.

【 授权许可】

Unknown